| Characteristic | Details |
|---|---|
| Active Ingredients | Sildenafil 100 mg, Tadalafil 20 mg |
| Indications | Erectile Dysfunction (ED) |
| Administration | Oral |
| Onset | 30-60 minutes |
| Duration | Up to 36 hours |
| Visit Sildalis Official Site | |
Pharmacokinetics
The pharmacokinetics of Sildalis combine the profiles of sildenafil and tadalafil. Sildenafil, primarily acting as a phosphodiesterase type 5 (PDE5) inhibitor, demonstrates rapid absorption. Its plasma concentration peaks within an hour post-dose. Tadalafil, also a PDE5 inhibitor, offers a longer half-life. Its effects endure, providing therapeutic benefit for up to 36 hours. When taken orally, both components exhibit swift gastrointestinal absorption.
Metabolism occurs mainly in the liver. Both sildenafil and tadalafil undergo hepatic transformation, leading to the formation of active metabolites. These are eventually excreted via urine and feces. The synergistic combination results in enhanced pharmacological action, offering a robust response to erectile dysfunction treatment.
The bioavailability of Sildalis requires attention. Food intake can impact sildenafil absorption. A high-fat meal may delay its absorption, diminishing the drug’s efficacy. Tadalafil’s bioavailability remains stable, unaffected by food. Consistent adherence to the prescribed regimen ensures optimal therapeutic outcomes.
Correct Use
Proper administration of Sildalis is crucial. Intake should be about 30-60 minutes before planned sexual activity. The tablet should be swallowed whole with water. It is vital to heed medical advice regarding dosage. Do not exceed one tablet in a 24-hour period. This minimizes the risk of adverse reactions.
Individual response may vary. Some may experience effects sooner. For others, onset may be delayed. Adherence to medical guidance ensures safe usage. Consult healthcare providers for personalized advice.
Adverse reactions may occur. Common side effects include headache, flushing, and dizziness. These are usually mild. Severe reactions necessitate immediate medical attention. Follow instructions carefully to maximize benefits.
Sildalis Contraindications
Not all individuals are candidates for Sildalis. Contraindications include hypersensitivity to sildenafil or tadalafil. Patients with significant cardiovascular disorders should avoid use. Conditions such as severe heart failure or unstable angina pose significant risks.
Concurrent use with nitrates is contraindicated. This combination may lead to severe hypotension. It is also inadvisable in patients with retinal disorders like retinitis pigmentosa. Caution is imperative in those with hepatic impairment.
Always disclose medical history to healthcare providers. This includes all medications currently taken. Contraindications ensure patient safety, preventing serious complications.
Sildalis Interactions
Drug interactions with Sildalis can alter its efficacy. Co-administration with nitrates is dangerous. This interaction risks a significant drop in blood pressure. Alpha-blockers may also potentiate hypotensive effects.
Certain antifungal agents and antibiotics can alter Sildalis metabolism. Drugs such as ketoconazole and erythromycin may increase plasma levels. Dose adjustments are crucial to manage these interactions.
Herbal supplements and over-the-counter medications may interfere. Ginseng and St. John’s Wort are notable examples. Consult healthcare professionals regarding potential interactions. This promotes safe and effective treatment.
Sildalis Signs and Symptoms of Overdose
Overdose symptoms manifest as severe adverse reactions. Headache, dizziness, and hypotension are common. Priapism, a prolonged erection, requires urgent care. Immediate intervention is crucial to prevent permanent damage.
Overdose may also exacerbate side effects. Visual disturbances, including blurred vision, can occur. Cardiovascular symptoms, such as tachycardia, may present. Close monitoring and prompt medical attention are essential.
Accurate dosage adherence is vital. Avoid exceeding recommended limits. In case of overdose, seek emergency assistance promptly. Effective management hinges on timely response.
Purchase Sildalis No Prescription
Acquiring Sildalis without a prescription is risky. It bypasses necessary medical oversight. Unregulated purchases may involve counterfeit products. These lack the efficacy and safety of approved formulations.
Consultation with healthcare providers is advisable. Prescriptions ensure appropriate dosage and usage. This mitigates risks associated with self-medication. Accessing Sildalis through legitimate channels guarantees quality.
Protect health by adhering to legal requirements. Avoid unauthorized sources to ensure genuine products. Prioritize safety and efficacy by following professional advice. This promotes optimal therapeutic results.